Sertraline and ibuprofen
Can I take sertraline with ibuprofen?
Sertraline and ibuprofen should be reviewed because SSRI and NSAID use can matter for bleeding risk, stomach symptoms, other medicines, and personal history.
Last reviewed: June 12, 2026
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Ask a clinician or pharmacist before using ibuprofen with sertraline, especially with ulcers, bleeding history, blood thinners, older age, pregnancy, or frequent NSAID use.
FAQ preview
Is this only a stomach upset question?
No. Stomach symptoms matter, but bleeding history, NSAID use, and other blood-thinning medicines also change the review.
Can this page stop sertraline?
No. Antidepressant changes should be handled by the prescriber.
What warning signs matter?
Black stools, vomiting blood, unusual bruising, severe stomach pain, fainting, or persistent bleeding need urgent medical review.
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