From structure to safety: Material characterization and toxicological evaluation...

연구 요약

From structure to safety: Material characterization and toxicological evaluation of Vanshlochan (Bambusa bambos (L.) voss [Poaceae]) using AI-assisted and In vivo approaches.

Journal of ethnopharmacology 학술지에 발표된 이 연구는 Bohra B, Yadav B, Kumar D 외 연구팀이 수행하였습니다.

이 연구는 'From structure to safety: Material characterization and toxicological evaluation of Vanshlochan (Bambusa bambos (L.) voss [Poaceae]) using AI-assisted and In vivo approaches.'에 대한 과학적 분석을 제공합니다.

핵심 내용

ETHNOPHARMACOLOGICAL RELEVANCE: Vanshlochan (Bambusa bambos (L.) Voss [Poaceae]) is a natural silica-rich exudate traditionally used in Ayurveda for respiratory diseases, inflammation, general debility, and bone-related disorders. Despite its long-standing traditional use, the physicochemical attributes and systemic safety of Vanshlochan have not been rigorously evaluated, limiting evidence-based validation. AIM OF THE STUDY: To characterize the elemental, structural, and surface chemistry of Vanshlochan and assess its safety using integrated AI-assisted toxicity prediction and OECD-compliant in vivo toxicological studies. MATERIALS AND METHODS: Microscopic, physicochemical, and phytochemical analyses were conducted in accordance with Ayurvedic Pharmacopeial standards. Material characterizations involved ICP-OES, FTIR, XRD, TGA/DTA, and XPS. Toxicity profiling included in silico prediction using ProTox-II and acute (OECD 420) and subacute (OECD 407) oral toxicity studies in Wistar rats with appropriate controls. RESULTS: ICP-OES identified silica as the dominant element with traces of Ca, Mg, K, and Fe. FTIR and XRD indicated an amorphous silicate matrix, while XPS showed SiO2, silicon oxycarbide, and aluminosilicate species. Vanshlochan exhibited high thermal stability up to 1200 °C. ProTox-II predicted low toxicity, which was consistent with in vivo findings showing no mortality, behavioural abnormalities, or organ-specific pathological changes. The no-observed-adverse-effect level (NOAEL) exceeded 2000 mg/kg/day. CONCLUSIONS: This study provides the first comprehensive structural and toxicological evaluation of Vanshlochan, confirming its physicochemical stability, biocompatibility, and systemic safety. These findings scientifically substantiate its traditional Ayurvedic use and support its safe application as a crude herbal material or nutraceutical ingredient.

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