Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate...

연구 요약

Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats.

Regulatory toxicology and pharmacology : RTP 학술지에 발표된 이 연구는 Fuller JC, Pitchford LM, Abumrad NN 외 연구팀이 수행하였습니다.

이 연구는 'Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats.'에 대한 과학적 분석을 제공합니다.

핵심 내용

2-Hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, can protect cells and tissues from oxidative stress. In this study, 2-HOBA acetate was orally administered to male and female rats for 90 consecutive days at doses of 100, 500, and 1000 mg·kg BW-1·d-1 (n = 20 per sex/group). Subchronic administration of 2-HOBA was well tolerated at all dose levels. 2-HOBA-treated male rats were slightly heavier in the last weeks of the study, but this difference was very small (<5%), did not show a dose-response relationship, and was not observed in female rats. Similarly, some statistically significant changes in serum biochemistry and hematology parameters were noted, but these were not considered to be of biological or toxicological significance. Sporadic differences in organ weights were observed between groups, but all were small (<10%) and unlikely to indicate toxicity. The incidence of histopathological lesions was similar between treated and control groups across all organs. Based upon these findings, the no-observed-adverse-effect level was determined to be ≥ 1000 mg·kg BW-1·d-1, which was the highest dose tested. These results further support no toxicity associated with oral consumption of 2-HOBA acetate in rats and the continued development of 2-HOBA as a dietary supplement or functional food.

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의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 30266239)