The Development of a Database for Herbal and Dietary Supplement Induced Liver To...

연구 요약

The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity.

International journal of molecular sciences 학술지에 발표된 이 연구는 Zhu J, Seo JE, Wang S 외 연구팀이 수행하였습니다.

이 연구는 'The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity.'에 대한 과학적 분석을 제공합니다.

핵심 내용

The growing use of herbal dietary supplements (HDS) in the United States provides compelling evidence for risk of herbal-induced liver injury (HILI). Information on HDS products was retrieved from MedlinePlus of the U.S. National Library of Medicine and the herbal monograph of the European Medicines Agency. The hepatotoxic potential of HDS was ascertained by considering published case reports. Other relevant data were collected from governmental documents, public databases, web sources, and the literature. We collected information for 296 unique HDS products. Evidence of hepatotoxicity was reported for 67, that is 1 in 5, of these HDS products. The database revealed an apparent gender preponderance with women representing 61% of HILI cases. Culprit hepatotoxic HDS were mostly used for weight control, followed by pain and inflammation, mental stress, and mood disorders. Commonly discussed mechanistic events associated with HILI are reactive metabolites and oxidative stress, mitochondrial injury, as well as inhibition of transporters. HDS⁻drug interactions, causing both synergistic and antagonizing effects of drugs, were also reported for certain HDS. The database contains information for nearly 300 commonly used HDS products to provide a single-entry point for better comprehension of their impact on public health.

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의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 30274144)

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