Pharmacokinetics Study of Herb-Drug Interaction of Berberine and Glipizide in Be...

연구 요약

Pharmacokinetics Study of Herb-Drug Interaction of Berberine and Glipizide in Beagle Dogs Using UPLC-MS/MS.

International journal of analytical chemistry 학술지에 발표된 이 연구는 Qi H, Wang W, Zhang X 외 연구팀이 수행하였습니다.

이 연구는 'Pharmacokinetics Study of Herb-Drug Interaction of Berberine and Glipizide in Beagle Dogs Using UPLC-MS/MS.'에 대한 과학적 분석을 제공합니다.

핵심 내용

Based on the establishment and validation of a UPLC-MS/MS method for detecting glipizide in beagle plasma, the herb-drug interaction (HDI) between berberine and glipizide was studied. After gradient elution separation of glipizide and internal standard, multiple reaction monitoring was used for detection in positive ion mode. The ion reactions used for quantitative analysis were glipizide m/z 446.0 ⟶ 321.0 and IS m/z 307.1 ⟶ 220.0. Six beagle dogs were treated with glipizide alone and berberine intervention, and the pharmacokinetic changes of glipizide were compared. The UPLC-MS/MS method has good linearity and the advantages of being green, simple, sensitive, and fast. After continuous administration of berberine to beagle dogs for 7 days, the pharmacokinetic process of glipizide changed with C max, AUC(0-t) and AUC(0-∞) increasing, t1/2 prolonging, and CL and Vd decreasing. When using combination therapy, attention should be paid to possible HDI.

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