Integrative Pharmacoinformatic and Experimental Validation of Indonesian Red Alg...

연구 요약

Integrative Pharmacoinformatic and Experimental Validation of Indonesian Red Algae as Novel Functional Food for Anti-Gastric Cancer Agents.

Molecular nutrition & food research 학술지에 발표된 이 연구는 Nurkolis F, Aldian FM, Alfaray RI 외 연구팀이 수행하였습니다.

이 연구는 'Integrative Pharmacoinformatic and Experimental Validation of Indonesian Red Algae as Novel Functional Food for Anti-Gastric Cancer Agents.'에 대한 과학적 분석을 제공합니다.

핵심 내용

Gastric cancer remains a major global health burden with limited therapeutic options due to resistance and toxicity of current treatments. Marine red algae-Gracilaria edulis, Eucheuma denticulatum, and Kappaphycus striatus-are underexplored sources of bioactive compounds that may offer multi-targeted, low-toxicity agents for gastric cancer therapy. This study integrated phytochemical profiling, structure-activity relationship (SAR) analysis, network pharmacology, molecular docking, molecular dynamics simulations, and in vitro validation. SAR and docking analyses showed strong affinities of key compounds, including camptothecin and 24(S),25-epoxycholesterol, with gastric cancer targets (PTGER3, TGFBR1, IGF1R, CDK6, BRD4). Molecular dynamics confirmed the stability of camptothecin-TGFBR1 interactions. Kappaphycus striatus extract (KSE) significantly downregulated TGF-β1 expression in MKN-45 cells in a dose-dependent manner. Cytotoxicity assays demonstrated that KSE, camptothecin, and 24(S),25-epoxycholesterol selectively inhibited AGS and MKN-45 gastric cancer cells while sparing normal epithelial cells. The findings highlight Indonesian red algae as promising, safe, and sustainable sources of multi-targeted anti-gastric cancer agents. In particular, KSE and its bioactive constituents exhibit both cytotoxic and epigenetic modulatory effects, underscoring their potential for future therapeutic development.

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의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41069123)