Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associa...

연구 요약

Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy.

Journal of advanced research 학술지에 발표된 이 연구는 Song G, Jung SJ, Jiao W 외 연구팀이 수행하였습니다.

이 연구는 'Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy.'에 대한 과학적 분석을 제공합니다.

핵심 내용

INTRODUCTION: Cardiac adipose tissue, which directly interfaces with the myocardium and vasculature, has a pivotal role in obesity-related cardiovascular pathology through its metabolic activity. This tissue contributes to cardiac remodeling through its regulation of lipid metabolism. Among the key organelles involved, peroxisomes have a central role in lipid metabolism, yet their contribution to obesity-induced cardiac dysfunction remains poorly understood. OBJECTIVES: This study investigated whether peroxisomal dysfunction in cardiac adipose tissue drives obesity-associated cardiac hypertrophy. METHODS: Using a high-fat diet (HFD)-induced obese rat model, we evaluated changes in cardiac adipose tissues, focusing on their browning capacity and metabolic functions. To investigate mechanistic effects, H9C2 cardiomyocytes were exposed either to fatty acids extracted from cardiac adipose tissues or conditioned medium derived from adipocytes treated with mitochondrial and peroxisomal inhibitors (Mdivi-1 or 10,12-tricosadiynoic acid). RESULTS: HFD-fed obese rats exhibited significant expansion of cardiac adipose tissues and cardiac hypertrophy, driven by impaired lipid metabolism and loss of browning capacity in cardiac fat associated with peroxisomal dysfunction. Treatment of H9C2 cardiomyocytes with conditioned medium from adipocytes with peroxisomal dysfunction induced collagen accumulation, increased expression of pro-inflammatory cytokines, and cellular hypertrophy, which recapitulates key pathological features observed in vivo. CONCLUSION: Our findings demonstrate that peroxisomal dysfunction in cardiac adipose tissue drives lipid metabolic reprogramming and contributes to obesity-related cardiac hypertrophy. Targeting peroxisomal function in cardiac fat could be a novel therapeutic approach to mitigate obesity-induced cardiovascular remodeling.

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