Therapeutic effects of Angelica gigas Nakai in experimental rat model of polycys...

연구 요약

Therapeutic effects of Angelica gigas Nakai in experimental rat model of polycystic ovary syndrome with network pharmacology.

Food science and biotechnology 학술지에 발표된 이 연구는 Lee B, Lee GW, Choi Y 외 연구팀이 수행하였습니다.

이 연구는 'Therapeutic effects of Angelica gigas Nakai in experimental rat model of polycystic ovary syndrome with network pharmacology.'에 대한 과학적 분석을 제공합니다.

핵심 내용

UNLABELLED: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women, characterized by disrupted ovarian function due to multiple factors. Angelica gigas Nakai (AG), known for its multi-compound and multi-target properties, was investigated as a potential therapy using an integrated approach combining network pharmacology and experimental validation. Active compounds of AG were matched with PCOS-related genes, and 45 overlapping targets were identified. Network analysis highlighted INS, LEP, and IGF1 as key nodes. KEGG enrichment indicated involvement of the AMPK signaling pathway. In vivo, estradiol valerate-induced PCOS rats treated with AG (1 mg/kg) displayed restored estrous cycles, normalized ovarian weight, reduced serum testosterone, and improved follicular maturation. Consistently, AG upregulated AMPK expression while downregulating INS, IGF1, Leptin, and PPAR-γ. These findings suggest that AG may serve as a promising therapeutic candidate for PCOS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10068-025-02019-2.

일반인을 위한 해석

구체적인 실천 사항은 담당 의사 또는 약사와 상담하시기 바랍니다.

실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41523694)