Effect of antifungal triazoles on vinca alkaloid neurotoxicity in pediatric pati...

연구 요약

Effect of antifungal triazoles on vinca alkaloid neurotoxicity in pediatric patients: A retrospective case series analysis and literature review.

Medicine 학술지에 발표된 이 연구는 Zhao Y, Ren X, Chen J 외 연구팀이 수행하였습니다.

이 연구는 'Effect of antifungal triazoles on vinca alkaloid neurotoxicity in pediatric patients: A retrospective case series analysis and literature review.'에 대한 과학적 분석을 제공합니다.

핵심 내용

To describe clinical manifestations, toxicities, and document measures for the management of neurotoxicity of vinca alkaloids (VAs) in pediatric cases. And discuss the difference between VAs monotherapy and combination of triazoles. A retrospective and descriptive analysis of adverse drug interaction (ADR) cases, which reported to the National Center for ADR monitoring from Peking University People's Hospital from January 2010 to December 2023, was performed. We also herein present a review of the literature on neurotoxicity caused by VAs. One hundred twenty-three patients were included. Median age was 4 years (0.1-18 years) with 86 (70.7%) having a diagnosis of acute lymphoblastic leukemia. The median number of VAs doses administered after which the neurotoxicity occurred was 3 doses (1-12 doses). The median time to clinical manifestations of adverse events was 21 days (1-140 days). The most common neuropathic toxicity is autonomic neuropathy, with paralytic ileus accounting for the highest proportion. More patients experienced severe neurotoxicity when treated with the combination of triazoles and VAs than with VAs monotherapy. In clinical practice, doctors and clinical pharmacists should pay attention to this adverse drug interaction. It is recommended to monitor for signs of neurotoxicity and consider the use of alternative antifungal agents in patients receiving VAs chemotherapy, in order to mitigate the occurrence of this adverse drug interaction.

일반인을 위한 해석

구체적인 실천 사항은 담당 의사 또는 약사와 상담하시기 바랍니다.

실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41630284)

📄 [전문 보기 (Markdown)](fulltext/41630284-effect-of-antifungal-triazoles-on-vinca-alkaloid-neurotoxici.md)