Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho...

연구 요약

Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signatures.

Scientific data 학술지에 발표된 이 연구는 Baek SJ, Lee H, Park SM 외 연구팀이 수행하였습니다.

이 연구는 'Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signatures.'에 대한 과학적 분석을 제공합니다.

핵심 내용

Jakyakgamcho-tang (JGT), the simplest form of herbal medicine, comprises Paeoniae Radix (PR) and Glycyrrhizae Radix et Rhizoma (GR). It has been used to treat muscle-related diseases and inflammation. However, its pharmacological effects may vary with the proportions of ingredients and preparatory factors such as the extraction method. Nevertheless, gene expression datasets systematically reflecting these variables are lacking. A total of 513 transcriptome profiles were created with three concentrations and three replicates of RNA-seq data. This dataset structure will enable multidimensional analysis of the effects of various JGT preparation factors on gene expression; these factors include the PR to GR proportional ratio (2:1, 1:1, and 1:2), solvent (water or 70% ethanol), and extraction method (combined or individual extraction method). The HepG2, C2C12, and PC12 cell lines were targeted. All raw and preprocessed data are available through GEO. Standardized metadata and ingredient data are also provided. This dataset provides a foundation for exploring traditional herbal formulations effects on cellular transcriptomic responses and can facilitate the scientific optimization of herbal medicines.

일반인을 위한 해석

구체적인 실천 사항은 담당 의사 또는 약사와 상담하시기 바랍니다.

실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41651870)

📄 [전문 보기 (Markdown)](fulltext/41651870-multidimensional-transcriptome-dataset-for-systematic-evalua.md)