Geriatric syndromes, comorbidities, and polypharmacy: Determinants of health-rel...

연구 요약

Geriatric syndromes, comorbidities, and polypharmacy: Determinants of health-related quality of life in hospitalized older adults in South India.

Geriatric nursing (New York, N.Y.) 학술지에 발표된 이 연구는 Syed J, Pereira P, Tejeswini CJ 외 연구팀이 수행하였습니다.

이 연구는 'Geriatric syndromes, comorbidities, and polypharmacy: Determinants of health-related quality of life in hospitalized older adults in South India.'에 대한 과학적 분석을 제공합니다.

핵심 내용

BACKGROUND: As the older adult population grows, there is an increasing need to understand how geriatric syndromes and comorbidities affect the health-related quality-of-life (HRQoL). This study aimed to examine the relationships among geriatric syndromes, comorbidities, polypharmacy, and HRQoL in hospitalized older adults. METHODS: This cross-sectional study was conducted over 14-months in a tertiary care hospital and included patients aged ≥60 years. HRQoL was assessed using the EQ-5D-5 L questionnaire, and geriatric syndromes were assessed using validated tools. Multivariate linear regression analysis was used to identify factors associated with HRQoL. RESULTS: Among 597 patients (mean age 72.80 ± 7.41 years), the mean EQ-5D-5 L index was 0.75 (SD: 0.26), showing significant decline with age (p = 0.039). High prevalence rates were observed for frailty (59.30 %), sarcopenia (51.42 %) and cognitive impairment (15.91 %). Comorbidity burden, frailty, and sarcopenia increased with age (p < 0.001, p = 0.016, and p < 0.001, respectively). HRQoL scores were negatively associated with the Charlson Comorbidity Index (CCI) (p < 0.001), frailty (p < 0.001), sarcopenia (p = 0.003), and polypharmacy (p = 0.041). Regression analysis showed that the No of comorbidities (p = 0.009), CCI (p = 0.015), length of hospital stay (p = 0.022), and sarcopenia (p = 0.009) negatively affected HRQoL, whereas cognitive impairment (p = 0.037) had a positive association. CONCLUSION: Although this study identified significant associations between geriatric syndromes and HRQoL, its cross-sectional nature precludes the establishment of causal-relationships. Longitudinal studies should further examine these relationships to develop effective intervention strategies that may improve geriatric care outcomes.

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