Potential integration of multiple organs-on-a-chip for comprehensive drug-drug i...

연구 요약

Potential integration of multiple organs-on-a-chip for comprehensive drug-drug interaction prediction.

Expert opinion on drug metabolism & toxicology 학술지에 발표된 이 연구는 Hsu EW, Wang K, Tsang YP 외 연구팀이 수행하였습니다.

이 연구는 'Potential integration of multiple organs-on-a-chip for comprehensive drug-drug interaction prediction.'에 대한 과학적 분석을 제공합니다.

핵심 내용

INTRODUCTION: Predicting drug - drug interactions (DDIs) is essential for safe, effective medication therapy, yet conventional in vitro assays and in silico models are not completely reliable in their assessments. Multi-organ-on-a-chip (MOC) platforms provide a more physiologically relevant approach that may improve in vitro DDI predictions, particularly for complex DDIs. AREAS COVERED: We outline current DDI workflows, their strengths and limitations, and how single-organ chips can produce quantitative absorption, distribution, metabolism, and excretion (ADME) and toxicity parameters relevant for DDI analysis. We then discuss the need for emerging MOC platforms and the unique advantages that they offer, highlighting case studies that capture more complex DDI scenarios, as well as body-on-a-chip prototypes integrated with mechanistic modeling. EXPERT OPINION: MOC systems are currently poised to complement, not replace, established in vitro and modeling approaches for DDI predictions. Near-term value lies in fit-for-purpose contexts of use, supplying physiologically grounded parameters and mechanistic insight to physiologically based pharmacokinetic (PBPK) modeling. With continued progress in addressing key challenges (e.g. physiological scaling, sorptive materials, microscale analytics, variability, throughput, and standardization), MOCs should mature into reliable tools to assist in DDI prediction, and potentially even qualified assays as part of regulatory DDI risk assessment frameworks.

일반인을 위한 해석

구체적인 실천 사항은 담당 의사 또는 약사와 상담하시기 바랍니다.

실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41701155)