Exploratory analysis of real-world use and safety of traditional Korean medicine...

연구 요약

Exploratory analysis of real-world use and safety of traditional Korean medicine in pediatric epilepsy: A retrospective observational study.

Medicine 학술지에 발표된 이 연구는 Choi SY, Kim TH, Han JH 외 연구팀이 수행하였습니다.

이 연구는 'Exploratory analysis of real-world use and safety of traditional Korean medicine in pediatric epilepsy: A retrospective observational study.'에 대한 과학적 분석을 제공합니다.

핵심 내용

Given the limitations of conventional antiepileptic drugs and the growing need for complementary approaches, traditional Korean medicine has gained interest as a potential treatment option for pediatric and adolescent epilepsy. However, real-world clinical data on its use and safety remain limited. This exploratory study aimed to retrospectively investigate the real-world clinical use and safety of traditional Korean medicine in this population by analyzing medical records from 2 Korean medicine hospitals. A total of 54 patients were included. Demographic characteristics, growth-related indicators, seizure-related indicators, treatment patterns, follow-up duration, antiepileptic drug use, and adverse events were reviewed retrospectively. The mean age at seizure onset was 4.9 ± 4.9 years. Over a mean follow-up duration of 21.6 months, patients had an average of 10.2 ± 13.6 clinical visits and received heterogeneous treatment patterns, including herbal medicine decoction, herbal medicine formulation, and acupuncture. Mean height increased from 122.4 ± 27.6 to 134.0 ± 24.5 cm, and mean weight increased from 29.6 ± 22.1 to 34.9 ± 20.5 kg. Mean seizure frequency decreased from 0.7 ± 1.2 times per day at baseline to 0.2 ± 0.5 times per day during the follow-up period (P = .002). Antiepileptic drug regimens remained largely unchanged during the study period among patients with available medication data. Mild adverse events were reported in 5 patients (nausea, abdominal pain, and diarrhea), all of which resolved without serious complications. This study provides real-world insights into the clinical use and tolerability of traditional Korean medicine treatment in pediatric and adolescent epilepsy. Although therapeutic efficacy cannot be established due to the absence of a control group, these findings offer foundational data to support future hypothesis-driven studies assessing the safety and potential effectiveness of traditional Korean medicine in this population.

일반인을 위한 해석

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실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41731823)

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