United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of g...

연구 요약

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.

Toxicology reports 학술지에 발표된 이 연구는 Oketch-Rabah HA, Roe AL, Rider CV 외 연구팀이 수행하였습니다.

이 연구는 'United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.'에 대한 과학적 분석을 제공합니다.

핵심 내용

As part of the United States Pharmacopeia's ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may contain hepatotoxic solvent residues, pesticide residues, pyrrolizidine alkaloids and elemental impurities, but no evidence of their involvement in GTE-induced liver injury was found during this review. GTE catechin profiles vary significantly with manufacturing processes. Animal and human data indicate that repeated oral administration of bolus doses of GTE during fasting significantly increases bioavailability of catechins, specifically EGCG, possibly involving saturation of first-pass elimination mechanisms. Toxicological studies show a hepatocellular pattern of liver injury. Published adverse event case reports associate hepatotoxicity with EGCG intake amounts from 140 mg to ∼1000 mg/day and substantial inter-individual variability in susceptibility, possibly due to genetic factors. Based on these findings, USP included a cautionary labeling requirement in its Powdered Decaffeinated Green Tea Extract monograph that reads as follows: "Do not take on an empty stomach. Take with food. Do not use if you have a liver problem and discontinue use and consult a healthcare practitioner if you develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice (yellowing of the skin or eyes)."

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의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 32140423)

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