The Association Between Polypharmacy, Low Appendicular Skeletal Muscle Mass Inde...

연구 요약

The Association Between Polypharmacy, Low Appendicular Skeletal Muscle Mass Index, and Physical Performance: A Cross-Sectional Study.

Gerontology 학술지에 발표된 이 연구는 Hung CD, Chang CW, Tu HP 외 연구팀이 수행하였습니다.

이 연구는 'The Association Between Polypharmacy, Low Appendicular Skeletal Muscle Mass Index, and Physical Performance: A Cross-Sectional Study.'에 대한 과학적 분석을 제공합니다.

핵심 내용

INTRODUCTION: In response to the rapidly growing elderly population, geriatric syndromes such as frailty, polypharmacy, and sarcopenia have gained significant attention due to their impact on aging-related health outcomes. To prevent functional decline, it is crucial to understand the relationship between physical performance and other potential confounding factors. This study aims to investigate how polypharmacy and other factors relate to physical performance. METHODS: This cross-sectional study included 445 participants aged over 20, surveyed via questionnaire. Polypharmacy was defined as the daily use of 8 or more pills. Body composition was assessed using bioelectrical impedance analysis, and physical performance was measured via the Time-Up-and-Go (TUG) and five times Sit-to-Stand (5xSTS) tests. RESULTS: The average age of participants was 64.22 years, with 11.0% were on polypharmacy. The mean appendicular skeletal muscle mass index, TUG test, and 5xSTS test were 7.40 kg/m², 8.29 seconds, and 9.33 seconds, respectively. Both physical performance tests correlated positively with age, low education, and polypharmacy, and negatively with appendicular skeletal muscle mass index. Polypharmacy, low muscle mass, and lower educational levels were associated with poorer physical performance. CONCLUSION: These findings highlight the importance of early prevention strategies to address polypharmacy, muscle loss, and low education, all of which are potentially modifiable risk factors. Poorer physical performance was linked to polypharmacy, low muscle mass, and lower educational levels, suggesting a need for additional research into these contributing risk factors.

일반인을 위한 해석

구체적인 실천 사항은 담당 의사 또는 약사와 상담하시기 바랍니다.

실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41746861)