Persimmon-induced excessive anticoagulation in a patient ...

연구 요약

Persimmon-induced excessive anticoagulation in a patient with mechanical heart valves receiving warfarin therapy: A case report.

Medicine 학술지에 발표된 이 연구는 Kim J, Lee S, Moon H 외 연구팀이 수행하였습니다.

핵심 내용

RATIONALE: Warfarin is a widely used vitamin K antagonist requiring strict international normalized ratio monitoring due to its narrow therapeutic window. While the interaction between warfarin and vitamin K-rich foods is well known, limited data exist regarding the anticoagulant effects of persimmons, a fruit rich in various bioactive compounds. PATIENT CONCERNS: A 51-year-old woman with a history of double mechanical valve replacement presented for routine follow-up. She reported no symptoms or changes in medication but had consumed unripe persimmons ("Dangam") daily for 2 weeks prior to a sudden elevation in coagulation parameters. DIAGNOSES: Routine laboratory testing revealed elevated prothrombin time and activated partial thromboplastin time without any signs of bleeding or other clinical abnormalities. The timing of the abnormal results suggested a possible food-drug interaction. INTERVENTIONS: The patient was advised to discontinue persimmon intake immediately. Warfarin dosage was reduced from 4.25 to 3.5 mg without administering vitamin K supplementation. Coagulation parameters were monitored during this adjustment period. OUTCOMES: Within 2 weeks, prothrombin time and activated partial thromboplastin time values returned to baseline. The patient remained stable on a slightly adjusted warfarin dose (3.25-3.9 mg), with no further abnormalities over the subsequent 3 years of follow-up.

일반인을 위한 해석

이 연구는 약물 또는 영양제의 안전한 사용에 관한 과학적 근거를 제공할 수 있습니다. 다만, 개별 연구 결과만으로 일반화하기는 어려우며, 추가적인 연구가 필요할 수 있습니다.

실천 사항

• 현재 복용 중인 약물이나 영양제에 대해 궁금한 점이 있다면 담당 의사 또는 약사와 상담하시기 바랍니다
• 약물이나 영양제의 용법·용량을 임의로 변경하지 마세요
• 이상 반응이 나타나면 즉시 전문가에게 문의하세요

의사/약사의 전문적 판단을 대체하지 않습니다 (PMID: 41790714)